Case of the Month #14 - Miller Fisher syndrome

Published 02/02/2022

What investigations might be helpful?

  • Largely a clinical diagnosis, based on history and clinical examination.
  • Guillain-Barré Disability Scale (Hughes disability score) can help stratify risk.
  • Lung function tests – Forced Vital Capacity can quantify any deterioration and help inform decisions on critical care referral and requirement for intubation.
  • CSF – may show elevated protein count, typically after 5-7 days of disease, or may point to alternative diagnosis.
  • Blood tests – raised IgG, antiganglioside GM1 antibody, GQ1b antibody in Miller Fisher variant.
  • Nerve conduction studies.
  • Infection screen.