Case of the Month #60 The Acidotic Coma: A Case of Unexplained Rigidity

Published 29/01/2026

Take home message

  • Collateral history should always be taken in patients presenting with a reduced level of consciousness. Relying solely on investigations can lead to misdiagnosis. 
  • Tirzepatide could precipitate Euglycaemic ketoacidosis and result in profound transient neurological symptoms and severe renal failure requiring RRT.
  • Severe Euglycaemic Ketoacidosis can be treated with the use of IV Insulin and IV Dextrose.